1.Guo M, Zhao K, Guo L, et al. Copper assisted sequence-specific chemical protein conjugation at a single backbone amide[J]. Nature Communications, 2023, 14(1): 8063.
2023年12月5日,西湖大学党波波团队在Nature Communications杂志在线发表题为“Copper assisted sequence-specific chemical protein conjugation at a single backbone amide” 的研究论文。此研究开发了一种基于主链酰胺键单一位点选择性的蛋白质化学偶联方法,用于蛋白质特定位点标记,抗体偶联药物制备。
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文章链接:https://doi.org/10.1038/s41467-023-43753-7
2.Ran X, Zheng J, Chen L, et al. Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH–Wild-Type High-Grade Gliomas[J]. Cancer Immunology Research, 2024, 12(2): 232-246.
近日,西湖大学生命科学学院谢琦研究员,联合浙二医院神经外科祝向东主任、华山医院神经外科秦智勇主任,在Cancer Immunology Research上发表题为“Single-cell transcriptomics reveals the heterogeneity of the immune landscape of IDH-wildtype high-grade gliomas”的研究论文,利用单细胞转录组测序技术,对IDH-野生型高级别胶质瘤肿瘤浸润的免疫细胞和配对的外周血单核细胞(peripheral blood mononuclear cells, PBMC)的免疫景观进行了深入的分析,并且发现了胶质瘤免疫治疗的潜在靶点。
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文章链接:https://aacrjournals.org/cancerimmunolres/article/doi/10.1158/2326-6066.CIR-23-0211/731721/Single-cell-transcriptomics-reveals-the