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西湖大学生医中心2025年8月科研支撑成果

作者:浏览量:时间:2025-11-14

1. Zhang, K., Fu, Y., Gou, W., Miao, Z., Tian, Y., Liang, Y., Liang, X., Shuai, M., Xiao, C., Wang, J., Xu, F., Jiang, Z., Gao, C., Ma, S., Ordovas, J. M., & Zheng, J. S. (2025). Quantification of personalized glycemic sensitivity to food and its potential for precision nutrition in a series of n-of-1 trials.The American journal of clinical nutrition,122(2), 502–512. 

原文链接:https://doi.org/10.1016/j.ajcnut.2025.04.015


2. Sun, H., Yao, X., Jiao, Y., Kong, X., Han, Y., Li, Y., Ge, J., Cao, Y., Lu, H., Wang, P., Xu, Y., Li, J., Ding, K., & Gao, X. (2025). DNA remnants in red blood cells enable early detection of cancer. Cell research, 35(8), 568–587. 

原文链接:https://doi.org/10.1038/s41422-025-01122-7


3. Li, Z., Liu, X., Yang, Q., Hu, J., Ma, S., Feng, S., & Wu, M. (2025). Activity-based crosslinking of JmjC lysine demethylases by unsaturated methyllysine mimics. Science China Chemistry, 68(10), 5132–5137. 

原文链接:https://doi.org/10.1007/s11426-025-2759-1


4. Xiao, X., Wang, C., Guo, X., Xi, F., Qian, Q., Liang, G., Chen, M., Sun, X., Szabo, B., Jing, M., & Piatkevich, K. D. (2025). Genetically encoded biosensor for monitoring spatiotemporal dynamics of CCR2 ligands in culture and in vivo. Nature methods, 22(8), 1731–1741. 

原文链接:https://doi.org/10.1038/s41592-025-02742-y


5. Lin, Z., Wang, C., Bai, H., Zhang, Y., Lin, M., Liu, X., Hu, T., & Meng, Y. (2025). Mycn Is Essential for Pubertal Mammary Gland Development and Promotes the Activation of Bcl11b-Maintained Quiescent Stem Cells. Cells, 14(16), 1239. 

原文链接:https://doi.org/10.3390/cells14161239


6. Jing, D., Kong, F., Lu, X., Huang, G., Huang, J., Wang, H., Shi, Y., & Wang, C. (2025). Structural basis of auxin binding and transport by Arabidopsis thaliana AUX1. Proceedings of the National Academy of Sciences of the United States of America, 122(31), e2513424122. 

原文链接:https://doi.org/10.1073/pnas.2513424122


7. Li, Y., Duan, D., Zhu, S., Liu, Z., Zhang, Q., & Wu, L. (2025). Genome-wide RNAi screening in C. elegans reveals OXPHOS and pyrimidine synthesis pathways as PKA regulators. Communications biology, 8(1), 1280. 

原文链接:https://doi.org/10.1038/s42003-025-08718-0


8. Tang, K., Zhou, L., Tian, X., Fang, S. Y., Vandenbulcke, E., Du, A., Shen, J., Cao, H., Zhou, J., Chen, K., Kim, H. R., Luo, Z., Xin, S., Lin, S. H., Park, D., Yang, L., Zhang, Y., Suzuki, K., Majety, M., Ling, X., … Chen, S. (2025). Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering. Nature biomedical engineering, 9(8), 1290–1308. 

原文链接:https://doi.org/10.1038/s41551-025-01371-2


9. Yang, X., Zhang, F., Wu, B., Liang, J., Zhou, L., Lu, H., Feng, Z., & Wang, H. (2025). Transition Metal Tunes Molecular Self-Assembly in Living Cells for Controlling Cell-Cell Crosstalk. ACS applied materials & interfaces, 17(32), 45569–45578. 

原文链接:https://doi.org/10.1021/acsami.5c10736


10. Zhou, L., Lu, L., Zhang, Y., Wang, J., Cheng, J., & Wang, H. (2025). Water Dynamics in the Formation of Single-Component-Based Multiphasic Droplets. Journal of the American Chemical Society, 147(34), 31290–31299. 

原文链接:https://doi.org/10.1021/jacs.5c10784


11. Sun, H., Wang, J., Xu, N., & Le, K. (2025). Quantitative proteomics analysis of papillary thyroid carcinoma reveals protein S, clusterin, and leucine-rich α-2-glycoprotein 1 as potential prognostic protein biomarkers. Medicine, 104(32), e43715. 

原文链接:https://doi.org/10.1097/MD.0000000000043715


12. Xu, M., Zhang, Q., Li, Y., Zhou, W., Lei, L., Lin, F., Kou, Y., & Tao, Z. (2025). A fungal chromatin remodeler drives transcription by establishing an open chromatin architecture and activated histone environment. Cell reports, 44(9), 116169. 

原文链接:https://doi.org/10.1016/j.celrep.2025.116169


13. Zhao, S., Guo, Y., Kuang, X., Li, X., Wu, C., Lin, P., Xie, Q., Zhai, Z., Kong, D., & Ma, X. (2025). Hemocytes facilitate interclonal cooperation-induced tumor malignancy by hijacking the innate immune system in Drosophila. The EMBO journal, 44(19), 5394–5428. 

原文链接:https://doi.org/10.1038/s44318-025-00547-5


14. Fang, R., Bai, L., Verheijen, B. M., Li, B., Dong, K., Paulo, J. A., Zhou, M., Chu, Y. C., Song, Y., Sherman, M. Y., Gygi, S., Field, C. M., Mitchison, T. J., & Lu, Y. (2025). Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation. Nature communications, 16(1), 7852. 

原文链接:https://doi.org/10.1038/s41467-025-62751-5


15. Yang, H., Shi, T., Dong, J., Zhang, T., Li, Y., Guo, Y., Yuan, Y., Yang, L., Dong, J. T., & Yan, R. (2025). Structural insights into the substrate transport mechanism of the amino acid transporter complex. The Journal of biological chemistry, 301(9), 110569. 

原文链接:https://doi.org/10.1016/j.jbc.2025.110569


16.Guo, C., Long, Z., Lin, P., Shen, Y., Zhong, Y., Qian, J., Yu, J., Zhao, W., Liu, F., Ma, Y., Zheng, J., Yang, J., Zhao, S., Ran, X., Xia, Z., Wu, C., Cai, Y., Wang, C., & Xie, Q. (2025). BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma. Cell reports. Medicine, 6(8), 102258. 

原文链接:https://doi.org/10.1016/j.xcrm.2025.102258