实验室：流式平台

职位：平台主管

西湖大学（云栖校区）3号楼512室

15863398535/0571-85273905

dingxilai@westlake.edu.cn

教育背景

2003/9-2010/01 中国科学院生物物理研究所生物化学与分子生物学博士

1999/9-2003/07 山东师范大学 应用化学 学士

工作经历

2015/12-2017/11 博士后

2018/05-至今主管

工作职责

领导平台的规划、设计与建设；领导平台工作人员制定平台发展规划，平台安全运行，平台人员培训等一系列政策及规章制度；负责平台的日常运行及相关的环境安全措施；根据学校发展需要，领导平台工程师制定平台的研究方向；根据学校和社会需要，提议和组织论证新设备的购置的必要性和可行性。

负责平台对内部和对外部用户的关系；制定平台的年度预算和相关项目的实施；负责相关大型设备的运行和员工培训及员工技能提升；监督平台各类耗材的采购，库存和补充；综合负责平台运行相关的安全。

发表文章

Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma.

Zhu M, Ding X, Zhao R, Liu X, Shen H, Cai C, Ferrari M, Wang HY, Wang RF.

J Control Release. 2018 Feb 28;272:72-82. doi: 10.1016/j.jconrel.2018.01.004. Epub 2018 Jan 8.

Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.

Yu X, Cai B, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su XZ, Wang RF.

Immunity. 2016 Nov 15;45(5):1093-1107. doi: 10.1016/j.immuni.2016.10.001. Epub 2016 Oct 25.

Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.

Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, Zhao W, Wei G, Cui J, Zhao K, Wang HY, Wang RF.

Nat Commun. 2014 Dec 22;5:5780. doi: 10.1038/ncomms6780.

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.

Leigh ND, Bian G, Ding X, Liu H, Aygun-Sunar S, Burdelya LG, Gudkov AV, Cao X.

PLoS One. 2014 Jan 14;9(1):e85587. doi: 10.1371/journal.pone.0085587. eCollection 2014.

The significance of comprehensive staging surgery in malignant ovarian germ cell tumors.

Liu Q, Ding X, Yang J, Cao D, Shen K, Lang J, Zhang G, Xin X, Xie X, Wu Y.

Gynecol Oncol. 2013 Dec;131(3):551-4. doi: 10.1016/j.ygyno.2013.08.016. Epub 2013 Sep 2.

Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect.

Bian G, Ding X, Leigh ND, Tang Y, Capitano ML, Qiu J, McCarthy PL, Liu H, Cao X.

J Immunol. 2013 Feb 1;190(3):1341-50. doi: 10.4049/jimmunol.1201554. Epub 2012 Dec 21.

A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.

Ding X, Bian G, Leigh ND, Qiu J, McCarthy PL, Liu H, Aygun-Sunar S, Burdelya LG, Gudkov AV, Cao X.

J Immunol. 2012 Nov 15;189(10):4719-27. doi: 10.4049/jimmunol.1201206. Epub 2012 Oct 8.

MGB-based one-step multiplex real-time PCR method for rapid detection of HPV.

Huang J, Gao C, Ding X, Qu S, Liu L, Wu W, Zhang L, Zhao J, Gao S.

Cancer Biomark. 2012-2013;12(3):107-13. doi: 10.3233/CBM-130298.

TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms.

Ding X, Yang W, Shi X, Du P, Su L, Qin Z, Chen J, Deng H.

J Immunol. 2011 Aug 1;187(3):1184-91. doi: 10.4049/jimmunol.1002902. Epub 2011 Jun 27.

Rapid estimation of binding activity of influenza virus hemagglutinin to human and avian receptors.

Cao Y, Koh X, Dong L, Du X, Wu A, Ding X, Deng H, Shu Y, Chen J, Jiang T.

PLoS One. 2011 Apr 13;6(4):e18664. doi: 10.1371/journal.pone.0018664.

Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection.

Yang W, Ding X, Deng J, Lu Y, Matsuda Z, Thiel A, Chen J, Deng H, Qin Z.

J Mol Med (Berl). 2011 Apr;89(4):399-409. doi: 10.1007/s00109-010-0711-5. Epub 2010 Dec 30.

Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B.

Xu D, Fu J, Jin L, Zhang H, Zhou C, Zou Z, Zhao JM, Zhang B, Shi M, Ding X, Tang Z, Fu YX, Wang FS.

J Immunol. 2006 Jul 1;177(1):739-47.